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Health Benefits of Nicotinamide Mononucleotide (NMN)

NMN Benefits

Nicotinamide Mononucleotide (NMN) and Ageing: Potential and Challenges

A summary of :
Recent research into nicotinamide mononucleotide and ageing a sponsored article which appeared on https://www.nature.com/articles/d42473-022-00002-7

What is NMN? 

  • NMN is a precursor to NAD+, a crucial enzyme for cell functions like metabolism, DNA repair, and growth.
  • NMN levels decline with age and are linked to age-related conditions.

NMN in animal models:

  • Studies show NMN supplementation improves healthspan and reduces age-related diseases in mice.
  • It increases energy metabolism, insulin sensitivity, and prevents age-linked gene expression changes.
  • NMN might protect neurons from damage and improve memory in animal models of Alzheimer’s disease.

NMN in humans:

  • Early clinical trials show NMN is safe in humans at specific doses.
  • One study observed improved insulin sensitivity in muscles but no other metabolic benefits.
  • NMN might not translate the same effects seen in animals due to species differences or dosage.

NMN and skin:

  • NMN combined with specific bacteria showed potential in protecting mouse skin from sun damage.
  • Researchers are developing methods to deliver NMN to human skin cells for anti-ageing effects.

Challenges and future directions:

  • More research is needed on NMN’s effects on the human body, including long-term safety and efficacy.
  • Studies are ongoing to understand NMN’s impact on metabolism, hormones, and overall health in humans.
  • Regulation and proper labeling of NMN-containing products are crucial for consumer safety.


While NMN shows promise in animal models, its effectiveness and safety in humans require further investigation. Ongoing clinical trials and research will provide a clearer picture of NMN’s potential as an anti-ageing intervention.

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